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  • 何良

    发布者:网信彩票精准计划群  发布时间:2019-06-26  浏览次数:1904

    、个人基本资料

    姓名:何良

    性别:

    出生年月:1987.7

    籍贯:广东阳春

    职位:教授,硕士生导师

     

    二、联系方式

    邮箱:heliang@scau.edu.cn

    通讯地址:广州市天河区华南农业大学网信彩票精准计划群应用化学系

    邮编:510642

     

    三、个人简介

    中共党员,理学博士,副教授,硕士生导师。2016年毕业于中山大学,获博士学位,师从毛宗万教授。迄今为止,以第一作者或通讯作者在Angew. Chem. Int. Ed.Chem. Sci.Eur. J. Med. Chem.Chem. Commun.等杂志上发表SCI论文10余篇,参与发表SCI论文10余篇。获授权中国专利1项。作为负责人主持国家自然科学基金项目等多项科研项目。主要承担《无机化学》、《配位化学》、《基础化学实验》等课程的教学工作。

     

    四、教育背景

    1. 2011.09-2016.06,中山大学,化学学院,化学生物学,博士(硕博连读,导师:毛宗万教授)

    2. 2007.09-2011.06,中山大学,化学学院,高分子材料与工程,学士

     

    、工作经历

    1. 2018.09至今,华南农业大学,网信彩票精准计划群,副教授/硕士生导师

    2. 2016.09-2018.08,中山大学,化学学院,特聘副研究员。

     

    科研方向

    所从事的学科领域为生物无机化学、化学生物学、分析化学等。研究方向主要包括:1、金属抗癌抗菌药物的设计、活性及机制研究;2、发光金属配合物在生物医学成像方面的应用;3、荧光分子探针及生物成像分析等。

     

    、科研论著

    1. Xuling Xue, Ying Fu, Liang He (Co-first author), Luca Salassa, Ling-Feng He, Yuan-Yuan Hao, Madeleine J. Koh, Clément Soulie, Russell J. Needham, Abraha Habtemariam, Claudio Garino, Kirill A. Lomachenko, Zhi Su*, Yong Qian, Martin J. Paterson*, Zong-Wan Mao*, Hong-Ke Liu*, Peter J. Sadler*. Photoactivated Osmium Arene Anticancer Complexes. Inorg. Chem., 2021, accepted.

    2. Dai-Hong Cai, Chun-Lian Zhang, Qi-Yan Liu, Liang He*, Yun-Jun Liu*, Ya-Hong Xiong, Xue-Yi Le*. Synthesis, DNA binding, antibacterial and anticancer properties of two novel water-soluble copper(II) complexes containing gluconate. Eur. J. Med. Chem., 2021, 213, 113182.

    3. Dai-Hong Cai, Hui?Wen Mo, Liang He*, Xue-Yi Le*. Crystal Structure, DNA Binding Properties and Biological Activities of a Ternary Mixed-Ligand Copper(II) Complex. Chin. J. Inorg. Chem., 2021, 37(1):74-84.

    4. Kang-Nan Wang, Xiang-Jun Peng, Yi Li, Hai-Tao Tang, Ying-Ming Pan*, Liang He*. Photostable fluorescent probes for 3D imaging and monitoring the metabolism of lipid droplets. Dyes and Pigments, 2020, 180, 108502.

    5. Zheng-Yin Pan, Dai-Hong Cai, Liang He*. Dinuclear phosphorescent rhenium(I) complexes as potential anticancer and photodynamic therapy agents. Dalton Trans., 2020, 49, 11583–11590.

    6. Wei-Wei Qin, Zheng-Yin Pan, Dai-Hong Cai, Yi Li, Liang He*. Cyclometalated iridium(III) complexes for mitochondria-targeted combined chemo-photodynamic therapy. Dalton Trans., 2020, 49, 3562–3569.

    7. Liang He*, Ming-Fang Zhang, Zheng-Yin Pan, Kang-Nan Wang, Zi-Jian Zhao, Yi Li, Zong-Wan Mao*. A mitochondria-targeted iridium(III)-based photoacid generator induces dual-mode photodynamic damage within cancer cells. Chem. Commun., 2019, 55, 10472–10475.

    8. Liang He*, Zheng-Yin Pan, Wei-Wei Qin, Yi Li,Cai-Ping Tan*, Zong-Wan Mao*. Impairment of the autophagy-related lysosomal degradation pathway by an anticancer rhenium(I) complex. Dalton Trans., 2019, 48, 4398–4404.

    9. Liang He, Jian-Jun Cao, Dong-Yang Zhang, Liang Hao, Ming-Fang, Zhang, Cai-Ping Tan, Liang-Nian Ji, Zong-Wan Mao*. Lipophilic phosphorescent iridium(III) complexes as one- and two-photon selective bioprobes for lipid droplets imaging in living cells. Sensor. Actuat. B-Chem., 2018, 262, 313–325.

    10.  Liang He, Kang-Nan Wang, Yue Zheng, Jian-Jun Cao, Ming-Fang Zhang, Cai-Ping Tan, Liang-Nian Ji, Zong-Wan Mao*. Cyclometalated iridium(III) complexes induce mitochondria derived paraptotic cell death and inhibit tumor growth in vivo. Dalton Trans., 2018, 47, 6942–6953.

    11.  Liang He, Cai-Ping Tan, Qian Cao, Zong-Wan Mao*. Application of Phosphorescent Cyclometalated Iridium (Ⅲ) Complexes in Cancer Treatment. Progress in Chemistry, 2018, 30, 1548–1556.

    12.  Liang He, Yi Li, Cai-Ping Tan*, Rui-Rong Ye, Mu-He Chen, Jian-Jun Cao, Liang-Nian Ji, Zong-Wan Mao*. Cyclometalated iridium(III) complexes as lysosome-targeted photodynamic anticancer and real-time tracking agents. Chem. Sci., 2015, 6, 5409–5418.(Back Cover)

    13.  Liang He, Cai-Ping Tan*, Rui-Rong Ye, Yi-Zhi Zhao, Ya-Hong Liu, Qiang Zhao, Liang-Nian Ji, Zong-Wan Mao*. Theranostic iridium(III) complexes as one- and two-photon phosphorescent trackers to monitor autophagic lysosomes. Angew. Chem. Int. Ed., 2014, 53, 12137–12141.

    14.  Liang He, Si-Yan Liao, Cai-Ping Tan*, Yi-Ying Lu, Cui-Xia Xu, Liang-Nian Ji, Zong-Wan Mao*. Cyclometalated iridium(III)–β-carboline complexes as potent autophagy-inducing agents. Chem. Commun., 2014, 50, 5611–5614.

    15.  Liang He, Si-Yan Liao, Cai-Ping Tan*, Rui-Rong Ye, Yu-Wen Xu, Meng Zhao, Liang-Nian Ji, Zong-Wan Mao*. Ruthenium–arene–β-carboline complexes as potent inhibitors of cyclin-dependent kinase 1: synthesis, characterization and anticancer mechanism studies. Chem. Eur. J., 2013, 19, 12152–12160.

    16.  Yue Zheng, Liang He, Dong-Yang Zhang, Cai-Ping Tan*, Liang-Nian Ji, Zong-Wan Mao*. Mixed-ligand iridium(III) complexes as photodynamic anticancer agents. Dalton Trans., 2017, 46, 11395–11407.

    17.  Rui-Rong Ye, Cai-Ping Tan*, Liang He, Mu-He Chen, Liang-Nian Ji, Zong-Wan Mao*. Cyclometalated Ir(III) complexes as targeted theranostic anticancer therapeutics: combining HDAC inhibition with photodynamic therapy. Chem. Commun., 2014, 50, 10945–10948.

    18.  Dong-Yang Zhang, Yue Zheng, Hang Zhang, Liang He, Cai-Ping Tan*, Jing-Hua Sun, Wei Zhang, Xingyun Peng, Qiuqiang Zhan, Liang-Nian Ji, Zong-Wan Mao*. Ruthenium complex-modified carbon nanodots for lysosome-targeted one- and two-photon imaging and photodynamic therapy. Nanoscale, 2017, 9, 18966–18976.

    19.  Yi Li, Cai-Ping Tan, Wei Zhang, Liang He, Liang-Nian Ji, Zong-Wan Mao*. Phosphorescent iridium(III)-bis-N-heterocyclic carbene complexes as mitochondria-targeted theranostic and photodynamic anticancer agent. Biomaterials, 2015, 39, 95–104.

     

    科研项目

    1. 广东省自然科学基金面上项目,基于磷光金属配合物的光致产酸剂用于乏氧肿瘤的双光子光动力治疗(2019A1515011280),2019.09-2022.09,10万元,主持

    2. 广州市科技计划项目,肿瘤微环境靶向激活的磷光金属配合物的设计、合成及抗癌活性研究(202102021223),2021.04-2023.03,5万元,主持

    3. 国家自然科学基金青年基金项目,靶向型磷光金属配合物诱导癌细胞免疫原性死亡的研究(21701195),2018.01-2020.12,25万元,主持

    4. 广东省自然科学基金博士科研启动项目,靶向型的磷光金属配合物作为抗癌诊疗药物的研究(2017A030310278),2017.05-2020.04,10万元,主持

    5. 高校基本科研业务费-中山大学青年教师培育项目,肿瘤微环境刺激响应的磷光金属配合物作为抗癌药物的研究,2017.01-2019.12,15万,主持

     

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